Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Bazaka, Kateryna, Jacob, Mohan V., Crawford, Russell J., and Ivanova, Elena P. (2012) Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms. Applied Microbiology and Biotechnology, 95 (2). pp. 299-311.

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Biomaterials play a fundamental role in disease management and the improvement of health care. In recent years, there has been a significant growth in the diversity, function, and number of biomaterials used worldwide. Yet, attachment of pathogenic microorganisms onto biomaterial surfaces remains a significant challenge that substantially undermines their clinical applicability, limiting the advancement of these systems. The emergence and escalating pervasiveness of antibiotic-resistant bacterial strains makes the management of biomaterial-associated nosocomial infections increasingly difficult. The conventional post-operative treatment of implant-caused infections using systemic antibiotics is often marginally effective, further accelerating the extent of antimicrobial resistance. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore sought. The surface modification of biomaterials has the potential to alleviate pathogenic biofouling, therefore preventing the need for conventional antibiotics to be applied.

Item ID: 22970
Item Type: Article (Research - C1)
ISSN: 0175-7598
Keywords: biomaterials, surface treatment, biofilm, bacterial attachment
Funders: Australian Research Council (ARC), Advanced Manufacturing CRC
Date Deposited: 15 Aug 2012 05:44
FoR Codes: 09 ENGINEERING > 0912 Materials Engineering > 091209 Polymers and Plastics @ 100%
SEO Codes: 96 ENVIRONMENT > 9604 Control of Pests, Diseases and Exotic Species > 960401 Border Biosecurity (incl. Quarantine and Inspection) @ 100%
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