Plasma assisted surface modification of organic biopolymers to prevent bacterial attachment

Bazaka, Kateryna, Jacob, Mohan V., Crawford, Russell J., and Ivanova, Elena P. (2011) Plasma assisted surface modification of organic biopolymers to prevent bacterial attachment. Acta Biomaterialia, 7 (5). pp. 2015-2028.

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Despite many synthetic biomaterials having physical properties that are comparable or even superior to those of natural body tissues, they frequently fail due to the adverse physiological reactions they cause within the human body, such as infection and inflammation. The surface modification of biomaterials is an economical and effective method by which biocompatibility and biofunctionality can be achieved while preserving the favorable bulk characteristics of the biomaterial, such as strength and inertness. Amongst the numerous surface modification techniques available, plasma surface modification affords device manufacturers a flexible and environmentally friendly process that enables tailoring of the surface morphology, structure, composition, and properties of the material to a specific need. There are a vast range of possible applications of plasma modification in biomaterial applications, however, the focus of this review paper is on processes that can be used to develop surface morphologies and chemical structures for the prevention of adhesion and proliferation of pathogenic bacteria on the surfaces of in-dwelling medical devices. As such, the fundamental principles of bacterial cell attachment and biofilm formation are also discussed. Functional organic plasma polymerised coatings are also discussed for their potential as biosensitive interfaces, connecting inorganic/metallic electronic devices with their physiological environments.

Item ID: 18813
Item Type: Article (Research - C1)
ISSN: 1878-7568
Keywords: bacterial adhesion; biofunctional coatings; plasma modification; anti-fouling coatings; organic polymers
Date Deposited: 27 Oct 2011 06:53
FoR Codes: 09 ENGINEERING > 0912 Materials Engineering > 091209 Polymers and Plastics @ 50%
09 ENGINEERING > 0912 Materials Engineering > 091205 Functional Materials @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970109 Expanding Knowledge in Engineering @ 100%
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