Doperminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia
McCarthy, C.S., Megaw, P., Devadas, M., and Morgan, I.G. (2007) Doperminergic agents affect the ability of brief periods of normal vision to prevent form-deprivation myopia. Experimental Eye Research, 84 (1). pp. 100-107.
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Placing a translucent diffuser over the eye of a chick causes the eye to grow excessively, resulting in form-deprivation myopia. For chickens kept on a 12:12 h light/dark cycle, removing the diffuser for 3 h during the light period protects against the excessive growth, but if the bird is kept in the dark for this 3-h period, the protective effect is abolished. Injecting dopamine agonists into the eye during this 3-h dark period restores the protective effect, which can be blocked by dopamine antagonists injected just prior to diffuser removal in the light. These responses are mediated by D2 receptors, suggesting that the protective effect of normal vision against form-deprivation is mediated through the stimulation of dopamine release and activation of D2-dopamine receptors.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||form-deprivation myopia; retina; dopamine; eye growth; chickens|
|FoR Codes:||06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060105 Cell Neurochemistry @ 50%|
06 BIOLOGICAL SCIENCES > 0606 Physiology > 060602 Animal Physiology - Cell @ 50%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920107 Hearing, Vision, Speech and Their Disorders @ 100%|
|Deposited On:||29 Mar 2010 08:04|
|Last Modified:||12 Feb 2011 23:41|
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