Clinical presentation of melioidosis in Queensland, Australia
Malczewski, Agnieszka B., Oman, Kimberly M., Norton, Robert E., and Ketheesan, Natkunam (2005) Clinical presentation of melioidosis in Queensland, Australia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99 (11). pp. 856-860.
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A retrospective study was performed on culture-positive patients (n = 57) with melioidosis presenting to the Townsville Hospital to define the epidemiology of the disease in Queensland, Australia. Mortality was 25% (n = 14) with a 9% (n = 5) relapse rate. At presentation, primary organs involved included the lungs (58%; n = 33), genitourinary system (11%; n = 6), skin and soft tissue (9%; n = 5), bone and joints (4%; n = 2), central nervous system (4%; n = 2), mycotic aneurysm (2%; n = 1) and peritonitis (2%; n = 1). No focus of infection could be identified in 12% of cases (n = 7). There was no significant difference in the clinical presentation of melioidosis in Queensland compared with the Northern Territory. Regional trends in the clinical presentation of melioidosis in Australia compared with Southeast Asia were confirmed. Risk factors for disease included diabetes (42%), excess alcohol consumption (42%), chronic lung disease (26%), immunosuppressive drug use (12%), renal disease (11%), malignancy (7%) and autoimmune disease (5%). No risk factors were identifiable in 18% of cases. The presence of multiple risk factors for melioidosis was not significantly associated with increased mortality (P > 0.05).
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Australia; Burkholderia pseudomallei; clinical presentation; epidemiology; melioidosis|
|FoR Codes:||06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060501 Bacteriology @ 50%|
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 50%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Deposited On:||11 Mar 2010 11:28|
|Last Modified:||18 Oct 2013 00:54|
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