Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats
Nimmo, A.J., Cernak, I., Heath, D.L., Hu, X., Bennett, C.J., and Vink, R. (2004) Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides, 38 (1). pp. 40-47.
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The present study has used capsaicin-induced neuropeptide depletion to examine the role of neurogenic inflammation in the development of edema and functional deficits following traumatic brain injury (TBI). Adult, male rats were treated with capsaicin (neuropeptide-depleted) or equal volume vehicle (controls) 14 days prior to induction of moderate/severe diffuse TBI. Injury in vehicle treated control animals resulted in acute (4–5 h) edema formation, which was confirmed as being vasogenic in origin by diffusion weighted magnetic resonance imaging and the presence of increased permeability of the blood–brain barrier (BBB) to Evans blue dye. There was also a significant decline in brain magnesium concentration, as assessed by phosphorus magnetic resonance spectroscopy, and the development of profound motor and cognitive deficits. In contrast, capsaicin pre-treatment resulted in a significant reduction in post-traumatic edema formation (p<0.001), BBB permeability (p<0.001), free magnesium decline (p<0.01) and both motor and cognitive deficits (p<0.001). We conclude that neurogenic inflammation may play an integral role in the development of edema and functional deficits following TBI, and that neuropeptides may be a novel target for development of interventional pharmacological strategies.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||capsaicin; diffuse brain injury; edema; magnesium; neuropeptides; neurotrauma|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%|
|Deposited On:||31 Mar 2010 09:39|
|Last Modified:||18 Oct 2013 00:52|
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