Decomposition of solids accompanied by melting - Bawn kinetics
Brown, Michael E., and Glass, Beverley D. (2003) Decomposition of solids accompanied by melting - Bawn kinetics. International Journal of Pharmaceutics, 254 (2). pp. 255-261.
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The book “Chemistry of the Solid State”, edited by W.E. Garner more than 50 years ago, contained a chapter (Chapter 10) by C.E.H. Bawn which dealt with the kinetics of the thermal decompositions of solids that are accompanied by some melting. Rate equations were derived and this model has become known as the Bawn model or as “Bawn kinetics”. This kinetic model has proved particularly useful in pharmaceutical stability studies. The isothermal curves of extent of decomposition, α, against time for this model are sigmoidal and the problems of distinguishing this model from other sigmoidal models (Prout–Tompkins, Avrami–Erofeev) have been examined. Under programmed temperature conditions, distinguishability becomes even more difficult.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Bawn model; kinetics; melting and decomposition; sigmoidal models; stability|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%|
|SEO Codes:||86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860899 Human Pharmaceutical Products not elsewhere classified @ 100%|
|Deposited On:||23 Mar 2010 09:28|
|Last Modified:||18 Oct 2013 00:48|
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