Models of type I (autoimmune) diabetes
Baxter, Alan G., and Duckworth, Rowena C. (2004) Models of type I (autoimmune) diabetes. Drug Discovery Today: Disease Models, 1 (4). pp. 451-455.
|PDF (Published version) - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader|
View at Publisher Website: http://dx.doi.org/10.1016/j.ddmod.2004.1...
Type 1 (autoimmune) diabetes is caused by T-cell autoreactivity resulting in destruction of the insulin-producing pancreatic islet β cells. Its aetiology involves complex interactions between multiple genetic and environmental factors, its pathogenesis involves interactions between many leukocyte subsets and their associated cytokines and its complications affect nearly every organ in the body. Modelling the disease is, therefore, the subject of much effort and surprising ingenuity. In this article, we review established and emerging models of the disease and give an indication of their use for different types of study.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||autoimmune disease; diabetes|
|FoR Codes:||06 BIOLOGICAL SCIENCES > 0604 Genetics > 060406 Genetic Immunology @ 100%|
|SEO Codes:||97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%|
|Deposited On:||20 Mar 2010 10:12|
|Last Modified:||13 Feb 2011 03:28|
Last 12 Months: 0
|Citation Counts with External Providers:|
Repository Staff Only: item control page