Adaptive immunity in melioidosis: a possible role for T cells in determining outcome of infection with Burkholderia pseudomallei
Barnes, J.L., Warner, J., Melrose, W., Durrheim, D., Speare, R., Reeder, J.C., and Ketheesan, N. (2004) Adaptive immunity in melioidosis: a possible role for T cells in determining outcome of infection with Burkholderia pseudomallei. Clinical Immunology, 113 (1). pp. 22-28.
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Melioidosis is a potentially fatal disease caused by the bacterium Burkholderia pseudomallei. Individuals with subclinical melioidosis have no apparent clinical signs or symptoms, and are identified only by positive serology. The present study is the first to investigate cell-mediated immune (CMI) responses following in vitro stimulation with B. pseudomallei antigens in peripheral blood mononuclear cells (PBMC), collected under field conditions in Papua New Guinea (PNG) from individuals with exposure to B. pseudomallei (n = 13). While five had a clinical history of melioidosis (C+), the remaining individuals (n = 8) were seropositive, yet healthy with no clinical history of melioidosis (S+/C−). Proliferation and IFN-γ production were significantly greater in lymphocyte cultures from S+/C− individuals compared to C+ individuals (P < 0.001 and P < 0.05, respectively). These findings demonstrate that compared to C+ patients, individuals with subclinical melioidosis have a stronger CMI response to B. pseudomallei antigens in vitro. Such a response may be essential for protection against disease progression.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Burkholderia pseudomallei; cell-mediated immunity; melioidosis; Papua New Guinea; serology|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Deposited On:||07 Jan 2010 09:12|
|Last Modified:||10 Jun 2013 00:52|
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|Citation Counts with External Providers:||Web of Science: 20|
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