Seroconversion to filarial antigens in Australian Defence Force personnel in Timor-Leste
Frances, Stephen, Baade, Lisa M., Kubofcik, Joseph, Nutman, Thomas B., Melrose, Wayne D., McCarthy, James S., and Nissen, Michael D. (2008) Seroconversion to filarial antigens in Australian Defence Force personnel in Timor-Leste. American Journal of Tropical Medicine and Hygiene, 78 (4). pp. 560-563.
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To investigate whether Australian soldiers were exposed to filarial parasites that cause lymphatic filariasis during a 6-month deployment to Timor-Leste, antifilarial antibody levels were measured in 907 soldiers using an enzyme linked immunosorbent assay (ELISA). Initial testing using Dirofilaria immitis antigen demonstrated that 49 of 907 (5.4%) soldiers developed antifilarial antibodies of the IgG1 subclass after deployment, whereas 1 of 944 (0.1%) seroconverted to the IgG4 subclass. When a sub sample of 88 D. immitis-reactive sera was subject to testing with an antifilarial antibody test using Brugia malayi antigen, 46 had elevated IgG antibodies, whereas 5 had elevated antibodies of the IgG4 subclass. A total of 24 soldiers seroconverted to B. malayi, as measured by parasite-specific IgG, whereas 1 seroconverted to IgG4. The relatively low number of seroconversions indicates a low but measurable risk of exposure to human filarial parasites among Australian soldiers deployed to Timor-Leste. However, to reduce the risk of exposure to these parasites, soldiers deploying to endemic areas should practice strict adherence to personal protective measures against mosquito bites.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Lymphatic Filariasis; defence force; Timor-Leste; seroconversion|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Deposited On:||22 Dec 2009 13:31|
|Last Modified:||18 Oct 2013 00:43|
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