HTR2A gene variation is involved in antidepressant treatment response
Lucae, Susanne, Ising, Marcus, Horstmann, Sonja, Baune, Bernhard T., Arolt, Volker, Muller-Myhsok, Bertram, Holsboer, Florian, and Domschke, Katharina (2010) HTR2A gene variation is involved in antidepressant treatment response. European Neuropsychopharmacology, 20 (1). pp. 65-68.
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DOI: 10.1016/j.euroneuro.2009.08.006
View at Publisher Website: http://dx.doi.org/10.1016/j.euroneuro.20...
Abstract
Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STAR*D (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STAR*D sample.
| ID Code: | 5271 |
|---|---|
| Item Type: | Article (Refereed Research - C1) |
| Keywords: | HTR2A; pharmacogenetics; SNP; treatment response; major depression; association study |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100% |
| SEO Codes: | 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100% |
| Deposited On: | 08 Feb 2010 09:53 |
| Last Modified: | 17 May 2013 00:44 |
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| Citation Counts with External Providers: | Web of Science: 15 |
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