Neutrophil labeling with [(90m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide
Gallagher, Hayley, Ramsay, Stuart C., Barnes, Jodie, Maggs, Jacqueline, Cassidy, Nathan, and Ketheesan, Natkunam (2006) Neutrophil labeling with [(90m)Tc]-technetium stannous colloid is complement receptor 3-mediated and increases the neutrophil priming response to lipopolysaccharide. Nuclear Medicine and Biology, 33 (3). pp. 433-439.
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99mTc]-technetium stannous colloid (TcSnC)-labeled white cells are used to image inflammation. Neutrophil labeling with TcSnC is probably phagocytic, but the phagocytic receptor involved is not known. We hypothesised that complement receptor 3 (CR3) plays a key role. Phagocytic labeling could theoretically result in neutrophil activation or priming, affecting the behaviour of labeled cells. Fluorescence-activated cell sorter (FACS) analysis side scatter measurements can assess neutrophil activation and priming.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||infection; phagocytosis; CR3; CD11b; labeled white blood cells|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 80%|
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 20%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 80%|
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 20%
|Deposited On:||20 Nov 2009 10:51|
|Last Modified:||18 Oct 2013 00:33|
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