Influence of sulfobutylether-β-cyclodextrin on the stability of S- and R- omeprazole
Agatonovic-Kustrin, Snezana, Williams, Desmond, Ibrahim, Nader, and Glass, Beverley D. (2007) Influence of sulfobutylether-β-cyclodextrin on the stability of S- and R- omeprazole. Current Drug Discovery Technologies, 4 (3). pp. 192-197.
|PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader|
View at Publisher Website: http://www.bentham.org/cddt/contabs/cddt...
Omeprazole (OME), a proton pump inhibitor used to treat acid reflux disease and gastric ulcers presents a formulation challenge due to its rapid decomposition at acidic and neutral pHs. Thus, the aim of this project was to investigate whether interaction with sulfobutylether-β-cyclodextrin (Captisol®-CD) could improve omeprazole stability and provide more efficient oral liquid formulations.
A stability-indicating high performance liquid chromatography assay allowed for the quantitation of S- and R-forms of OME in the presence and absence of Captisol®-CD. The developed method was validated to discriminate between OME and its degradation products and used to describe the kinetic model of OME at different pH values over a period of 36 days.
Calculated degradation constants (kobs), were directly correlated with the H+ concentrations of the solutions regardless of whether the omeprazole was complexed with the Captisol®-CD or not. Moreover, the pH-rate profile curve indicated that in all cases, maximum stability was achieved at pH 11. Though it was anticipated that interaction of OME with Captisol®-CD might increase the relative stability of OME at a lower pH, the cavity of the cyclodextrin was too small to allow the inclusion to occur. However the R-isomer of OME, both in the presence or absence of the cyclodextrin appeared to be slightly less stable than the corresponding S-form at the same pH conditions.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Captisol®-CD; interaction; omeprazole; stability; pH|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified @ 100%|
|SEO Codes:||92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%|
|Deposited On:||09 Jun 2009 10:43|
|Last Modified:||02 Nov 2012 08:59|
Last 12 Months: 0
|Citation Counts with External Providers:|
Repository Staff Only: item control page