60 Minutes of Cardiac Rescue and Stabilization with a Small Intravenous Bolus of Adenocaine Following 8 Minutes of Asphyxial Hypoxia in the Rat in Vivo: Effect of Therapeutic Hypothermia.
Djabir, Yulia Y., and Dobson, Geoffrey P. (2011) 60 Minutes of Cardiac Rescue and Stabilization with a Small Intravenous Bolus of Adenocaine Following 8 Minutes of Asphyxial Hypoxia in the Rat in Vivo: Effect of Therapeutic Hypothermia. Circulation, 124 (21 Supplement). p. 1.
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Sudden cardiac death claims more than 7,000,000 lives per year globally and a survival rate of 2 to 8% for out-of-hospital cardiac arrest (OHCA) victims has not improved in 30 years. Previously we reported that Adenocaine (adenosine and lidocaine) can arrest and reanimate the heart for use in cardiac surgery/transplantation, and that 7.5% NaCl/Adenocaine/Mg2+ can resuscitate the rat following severe hemorrhagic shock. Our aim was to examine Adenocaine's ability to rescue and stabilize the heart following 8 min of asphyxial hypoxia in the rat model of cardiac arrest at warm (37°C) and cold (rectal 32-33°C) temperatures.
|Item Type:||Article (Abstract)|
|Keywords:||cardiopulmonary resuscitation, sudden cardiac death, ventricular fibrillation, cardioprotection|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%|
|Deposited On:||04 Apr 2012 17:03|
|Last Modified:||04 Apr 2012 18:00|
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