Hepatic coenzyme Q redox balance of fishes as a potential bioindicator of environmental contamination by polycyclic aromatic hydrocarbons
Hasbi, Ghitarina, de Nys, Rocky, Burns, Kathryn, Whalan, Stephen, and Dunlap, Walter C. (2011) Hepatic coenzyme Q redox balance of fishes as a potential bioindicator of environmental contamination by polycyclic aromatic hydrocarbons. Biology Letters, 7 (1). pp. 123-126.
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View at Publisher Website: http://dx.doi.org/10.1098/rsbl.2010.0600
In this communication, we introduce a novel biomarker of aquatic contamination based on the xenobiotic-induced response of the hepatic coenzyme Q (CoQ) redox balance of fishes to polycyclic aromatic hydrocarbons (PAHs). The method is demonstrated by comparing changes in the liver CoQ redox balance with that measured using the CYP1A-based, 7-ethoxyresofurin-O-deethylase activity assay, on administration of benzo[a]pyrene (BaP) and β-naphthoflavone (BNF) to Barramundi (Lates calcarifer). Both assays showed comparable dose-dependent effects in fish treated with BaP or BNF. Perturbation in the constitutive hepatic CoQ redox balance of fishes may thus provide a simple biomarker of aquatic PAH contamination.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||pollution biomarker; coenzyme Q; EROD; Barramundi|
|FoR Codes:||07 AGRICULTURAL AND VETERINARY SCIENCES > 0704 Fisheries Sciences > 070401 Aquaculture @ 50%|
06 BIOLOGICAL SCIENCES > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified @ 50%
|SEO Codes:||83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8301 Fisheries - Aquaculture > 830199 Fisheries - Aquaculture not elsewhere classified @ 100%|
|Deposited On:||13 Jun 2012 10:04|
|Last Modified:||18 Oct 2013 01:27|
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