Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs
Campbell, Bronwyn E., Boag, Peter R., Hofmann, Andreas, Cantacessi, Cinzia, Wang, Conan K., Taylor, Paul, Hu, Min, Sindhu, Zia-ud-Din, Loukas, Alex, Sternberg, Paul W., and Gasser, Robin B. (2011) Atypical (RIO) protein kinases from Haemonchus contortus — Promise as new targets for nematocidal drugs. Biotechnology Advances, 29 (3). pp. 338-350.
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Almost nothing is known about atypical kinases in multicellular organisms, including parasites. Supported by information and data available for the free-living nematode, Caenorhabditis elegans, and other eukaryotes, the present article describes three RIO kinase genes, riok-1, riok-2 and riok-3, from Haemonchus contortus, one of the most important parasitic nematodes of small ruminants. Analyses of these genes and their products predict that they each play critical roles in the developmental pathways of parasitic nematodes. The findings of this review indicate prospects for functional studies of these genes in C. elegans (as a surrogate) and opportunities for the design of a novel class of nematode-specific inhibitors of RIO kinases. The latter aspect is of paramount importance, given the serious problems linked to anthelmintic resistance in parasitic nematode populations of livestock.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||parasite; Haemonchus contortus; RIO kinases; structure; * relationships; inferred function; drug targets|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Deposited On:||29 Feb 2012 10:06|
|Last Modified:||04 Jun 2013 02:04|
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|Citation Counts with External Providers:||Web of Science: 7|
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