A SPE-LC-MS/MS method for the detection of low concentrations of pharmaceuticals in industrial waste streams
Deegan, Ann-Marie, Cullen, Mark, Oelgemoeller, Michael, Nolan, Kieran, Tobin, John, and Morrissey, Anne (2011) A SPE-LC-MS/MS method for the detection of low concentrations of pharmaceuticals in industrial waste streams. Analytical Letters, 44 . pp. 2808-2820.
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A SPE-LC-MS/MS method was developed and validated for the determination of three active pharmaceutical ingredients in the wastewater of a chemical synthesis production facility. The SPE-LC-MS/MS method was validated in actual influent and effluent samples. Linearity, LOD, LOQ, repeatability, intermediate precision, and recovery were determined. The LC-MS/MS method was used for an on-going monitoring program for these pharmaceuticals in wastewater. The method development techniques, validation procedures, and results from real wastewater samples are presented in this paper.
|Item Type:||Article (Refereed Research - C1)|
Corresponding author: email@example.com
|Keywords:||mass spectrometry; pharmaceuticals; solid phase extraction; wastewater|
|FoR Codes:||03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030599 Organic Chemistry not elsewhere classified @ 50%|
03 CHEMICAL SCIENCES > 0301 Analytical Chemistry > 030108 Separation Science @ 50%
|SEO Codes:||97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%|
|Deposited On:||07 Dec 2011 14:56|
|Last Modified:||18 Oct 2013 01:23|
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