Squires, Richard, Watson, Penny, and Wallace, Melissa (2008) Feline Glomerulonephritis. In: Vetstream FELIS. Vetstream, UK, pp. 1-4.
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• Cause: deposition or in situ formation of antigen-antibody complexes in the basement membranes of glomerular capillaries in the kidneys.
• Signs: ususally no clinical signs until advanced. Proteinuria leads to hypoalbuminemia and sometimes to ascites or edema. Severe glomerular damage leads to loss of nephrons and eventually to renal failure (causing polydipsia/polyuria, inappetence, vomiting).
• Diagnosis: urine analysis, serum chemistry profile, histopathologic examination of kidney biopsy.
• Treatment: detect and eliminate the underlying source of antigen, if possible. Special diet, angiotensin-converting enzyme (ACE) inhibition, +/- low-dose aspirin (with great care), +/- immunosuppressant/immunomodulator therapy.
• Prognosis: variable. Some cases progress rapidly despite therapy, others remain stable for prolonged periods. Many undetected cases probably go on to develop renal failure and are diagnosed at that stage. If complicated by thromboembolism, eg pulmonary or caudal aortic, prognosis is poor.
|Item Type:||Book Chapter (Reference)|
This is a Vetstream FELIS peer reviewed journal article that was first published online in November 2008. It is updated quarterly.
|FoR Codes:||07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070706 Veterinary Medicine @ 100%|
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|Deposited On:||27 Sep 2011 11:36|
|Last Modified:||27 Sep 2011 11:37|
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