Update on retroviral infections in NZ cats
Squires, R.A. (1999) Update on retroviral infections in NZ cats. VetLearn Foundation Seminar Proceedings, 191 . pp. 109-124.
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[Extract] Retroviruses are single-stranded RNA viruses which, upon infection of a cell, transcribe their RNA genome into double-stranded DNA (dsDNA; see figure 1). They achieve this by use of their viral enzyme reverse transcriptase (RT). The viral dsDNA can then become stably integrated into host cellular chromosomal DNA as a "retroviral provirus". This retrograde flow of genetic information gives the retroviral family its name.
Retroviruses have been shown to cause a profusion of different diseases, including neoplastic, immunologic, degenerative, and proliferative disorders. Almost all families of animal DNA virus can cause neoplasia, but retroviruses are alone among the RNA viruses in manifesting oncogenicity. Perhaps this is because retroviruses are the only RNA viruses that replicate their genomes through a DNA intermediate. Intimate, persistent association between chromosomally-integrated viral DNA and cellular sequences may be important in the process of viral neoplastic transformation of cells.
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|Last Modified:||14 Jun 2012 17:21|
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