Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression
Roomberg, Alicia, Kling, Jessica, Fromm, Phillip, and Korner, Heinrich (2010) Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression. Immunology and Cell Biology, 88 (8). pp. 842-845.
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View at Publisher Website: http://dx.doi.org/10.1038/icb.2010.54
The effective maturation of dendritic cells (DC) is complex and highly regulated and requires the presence of a variety of signals. Tumor necrosis factor (TNF) and its receptors or innate pattern recognition receptors such as the toll-like receptors have been shown to contribute to this process. DC derived from bone marrow cells in the presence of granulocyte/macrophage colony-stimulating factor can be used as a model to ascertain the contribution of different signals to DC maturation. Analysis of DC activated by addition of the mycobacterial vaccine strain Bacillus Calmette-Guérin showed that of the effector molecules studied only interleukin-10 expression was significantly reduced in TNF-negative (B6.TNF−/−) DC. Another effector molecule produced by DC, inducible nitric oxide synthase, was largely unchanged.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||mycobacteria; tumor necrosis factor; interleukin-10; dendritic cells|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110704 Cellular Immunology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%|
|Deposited On:||30 May 2011 13:42|
|Last Modified:||24 May 2013 01:34|
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