Developing vaccines to combat hookworm infection and intestinal schistosomiasis
Hotez, Peter J., Bethony, Jeffrey M., Diemert, David J., Pearson, Mark, and Loukas, Alex (2010) Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Nature Reviews Microbiology , 8 (11). pp. 814-826.
|PDF (Published Version) - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader|
View at Publisher Website: http://dx.doi.org/10.1038/nrmicro2438
Hookworm infection and schistosomiasis rank among the most important health problems in developing countries. Both cause anaemia and malnutrition, and schistosomiasis also results in substantial intestinal, liver and genitourinary pathology. In sub-Saharan Africa and Brazil, co-infections with the hookworm, Necator americanus, and the intestinal schistosome, Schistosoma mansoni, are common. The development of vaccines for these infections could substantially reduce the global disability associated with these helminthiases. New genomic, proteomic, immunological and X-ray crystallographic data have led to the discovery of several promising candidate vaccine antigens. Here, we describe recent progress in this field and the rationale for vaccine development.
|Item Type:||Article (Refereed Research - C1)|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Deposited On:||10 May 2011 19:34|
|Last Modified:||08 Jun 2013 01:36|
Last 12 Months: 0
|Citation Counts with External Providers:||Web of Science: 57|
Repository Staff Only: item control page