Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patients
Plasmeijer, Elsemieke I., Neale, Rachel E., Buettner, Petra G., de Koning, Maurits N.C., ter Schegget, Jan, Quint, Wim G.V., Green, Adele C., and Feltkamp, Mariet C.W. (2010) Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patients. International Journal of Cancer, 126 (11). pp. 2614-2621.
|PDF (Published Version) - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader|
View at Publisher Website: http://dx.doi.org/10.1002/ijc.24991
Human papillomaviruses from the genus beta (betaPV) are a possible cause of cutaneous squamous cell carcinoma (SCC). We compared the betaPV infections in SCC and in sets of cutaneous tissues collected from a series of individual SCC patients to determine concordance and to assess the adequacy of eyebrow hairs as noninvasive markers of betaPV infection. Biopsies of SCC tumors, perilesional tissue, normal skin from the mirror image of nonfacial SCC and plucked eyebrow hairs were collected from 21 patients with incident SCC living in Queensland, Australia. These were tested for the presence of DNA from 25 different betaPV types. Overall prevalence of betaPV was high in every sample type, ranging from 81% to 95%. The median number of types was significantly higher in the SCC tumour (6), perilesional skin (5) and eyebrow hairs (5) than in normal skin (2). Comparing SCC tissue with other sample types within patients showed 63 overlapping infections with eyebrow hairs (71%; 95% CI: 60–80); 56 with perilesional skin samples (63%; 95% CI: 52–73) and 23 with normal skin samples (26%; 95% CI: 17–36). The sensitivity of eyebrow hair testing for detection of betaPV in the tumor was 82% (95% CI: 57–96) with concordance defined as 50% of betaPV types in common and 29% (95% CI: 10–56) for 100% concordance. These findings support the concept that perilesional skin represents an area of field change involving betaPV preceding SCC development and indicate that eyebrow hairs can serve to some degree as an easily collected marker of tumor betaPV status in epidemiological studies.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||betapapillomavirus, squamous cell carcinoma, field change|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110804 Medical Virology @ 50%|
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 50%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%|
|Deposited On:||07 May 2011 11:20|
|Last Modified:||24 May 2013 01:30|
Last 12 Months: 0
|Citation Counts with External Providers:||Web of Science: 10|
Repository Staff Only: item control page