Is Penicillium citrinum implicated in sago hemolytic disease?
Atagazli, Latifeh, Greenhill, Andrew R., Melrose, Wayne, Pue, Aisak G., and Warner, Jeffrey M. (2010) Is Penicillium citrinum implicated in sago hemolytic disease? Southeast Asian Journal of Tropical Medicine and Public Health, 41 (3). pp. 641-646.
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Sago hemolytic disease (SHD) is an acute hemolytic syndrome affecting rural Papua New Guineans who depend on the starch of Metroxylon sagu as a staple carbohydrate. It is a suspected mycotoxicosis associated with fungal succession in stored and perhaps poorly fermented sago. Despite a mortality rate of approximately 25%, little is know about the disease. Recent studies have identified Penicillium citrinum as a possible candidate in the etiology of SHD. This is based on the frequency of isolation from sago starch and the hemolytic nature of the organism as demonstrated when cultured on sheep and human blood agar. A highly non-polar lipophilic P. citrinum fraction from C18 solid phase extraction demonstrated high hemolytic activity in a semi-quantitative assay using both mouse and human erythrocytes. When the red cell membrane proteins were subjected to sodium dodecyl-sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) separation, cleavage of protein band 3 and spectrin was demonstrated. This breach of major structural red cell proteins is consistent with the severe hemolysis found in vivo. Our findings warrant further investigation into the hemolytic activity of P. citrinum and its role as the etiological agent of SHD.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||Penicillium citrinum, sago hemolytic disease, mycotoxicosis|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110303 Clinical Microbiology @ 50%|
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060501 Bacteriology @ 50%
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%|
|Deposited On:||16 Dec 2010 12:18|
|Last Modified:||18 Oct 2013 01:09|
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