Short report: molecular genetic characterization of an unusually severe case of hydatid disease in Alaska caused by the cervid strain of Echinococcus granulosus
McManus, Donald P., Zhang, Lihua, Castrodale, Louisa J., Le, Thanh Hoa, Pearson, Mark, and Blair, David (2002) Short report: molecular genetic characterization of an unusually severe case of hydatid disease in Alaska caused by the cervid strain of Echinococcus granulosus. American Journal of Tropical Medicine & Hygiene, 67 (3). pp. 296-298.
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Distinct Echinococcus granulosus life cycle patterns have been described in North America: domestic and sylvatic. Gene sequences of the sylvatic E. granulosus indicate that it represents a separate variant. Case-based data have suggested that the course of sylvatic disease is less severe than that of domestic disease, which led to the recommendation to treat cystic echinococcosis patients in the Arctic by careful medical management rather than by aggressive surgery. We recently reported the first two documented E. granulosus human cases in Alaska, with accompanying severe sequelae. Here we describe the results of molecular genetic analysis of the cyst material of one of the subjects that supported identification of the parasite as the sylvatic (cervid) strain and not the domestic (common sheep strain), which was initially thought to be implicated in these unusually severe Alaskan cases.
|Item Type:||Article (Refereed Research - C1)|
|FoR Codes:||06 BIOLOGICAL SCIENCES > 0608 Zoology > 060899 Zoology not elsewhere classified @ 100%|
|SEO Codes:||97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 100%|
|Deposited On:||04 Dec 2010 21:37|
|Last Modified:||14 May 2013 01:18|
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|Citation Counts with External Providers:||Web of Science: 21|
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