In vivo image-guided 1H-magnetic resonance spectroscopy of the serial development of heptocarcinogensis in an experimental animal model
Foley, L.M., Towner, R.A., and Painter, D.M. (2001) In vivo image-guided 1H-magnetic resonance spectroscopy of the serial development of heptocarcinogensis in an experimental animal model. Biochimica et Biophysica Acta, 1526 (3). pp. 230-236.
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Histology on a core or open biopsy is considered the gold standard for the diagnosis of tumours. While the non-invasive technique of magnetic resonance imaging can direct some of the decision diagnostic making, it has limitations and disadvantages, that can be partly overcome with the use of in vivo magnetic resonance spectroscopy (MRS). In vivo MRS is able to provide a specific biochemical profile on tumour tissue, compared with normal tissue. The capability of this technique is demonstrated here by the long-term development of hepatocellular carcinoma in an animal model. It allows the observation of the biochemical changes that occur in tumour tissue during its progression from preneoplastic nodules to hepatocellular carcinoma. Specifically the changes in the lipid profiles of tumour tissue at various stages of development are observed with proton (1H) MRS. Significant increases occurred in the lipid acyl chain methylene and methyl hydrogens during the early developmental stages of hepatocarcinogenesis, whereas during later stages associated with tumour development there was a significant increase in the levels of olefinic acyl chain hydrogens from unsaturated lipids. It is anticipated that this model will precede the application of the same technology to the non-invasive diagnosis and grading of human hepatocellular carcinoma.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||animal models; heptocarcinogensis; heptocellular carcinoma; H-magnetic resonance spectroscopy; magnet resonance|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110320 Radiology and Organ Imaging @ 50%|
11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids @ 25%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111299 Oncology and Carcinogenesis not elsewhere classified @ 25%
|SEO Codes:||86 MANUFACTURING > 8608 Human Pharmaceutical Products > 860802 Human Diagnostics @ 51%|
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 49%
|Deposited On:||13 Aug 2012 16:28|
|Last Modified:||14 Jan 2013 13:57|
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