Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes
Pisani, Michelle J., Weber, Daniel K., Heimann, Kirsten, Collins, J. Grant, and Keene, F. Richard (2010) Selective mitochondrial accumulation of cytotoxic dinuclear polypyridyl ruthenium(II) complexes. Metallomics, 2 (6). pp. 393-396.
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DOI: 10.1039/c004922k
View at Publisher Website: http://dx.doi.org/10.1039/c004922k
Abstract
The lipophilic ligand-bridged dinuclear cation Rubb16 is significantly cytotoxic and preferentially accumulates in the mitochondria of the L1210 murine leukemia cancer cell line.
| ID Code: | 11649 |
|---|---|
| Item Type: | Article (Refereed Research - C1) |
| Keywords: | mitochondria; ruthenium; dinuclear; cytotoxicity; cancer |
| FoR Codes: | 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030201 Bioinorganic Chemistry @ 50% 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030207 Transition Metal Chemistry @ 50% |
| SEO Codes: | 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 80% 97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 20% |
| Funders: | Australian Research Council |
| Deposited On: | 05 Aug 2010 15:36 |
| Last Modified: | 17 Jun 2013 01:17 |
| Downloads: | Total: 3 Last 12 Months: 2 |
| Statistics: | More Statistics |
| Citation Counts with External Providers: | Web of Science: 8 |
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