Risk of contamination of germoplasm during cyropreservation and cyrobanking in IVF units
Bielanski, A., and Vajta, G. (2009) Risk of contamination of germoplasm during cyropreservation and cyrobanking in IVF units. Human Reproduction, 24 (10). pp. 2457-2467.
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Cryopreservation of sperm, embryos and, more recently, oocytes plays an important and increasing role in assisted reproduction, due to improvements of old, and introduction of new technologies. In parallel, concerns are increasing about the technical and biological safety of these procedures. However, published data regarding the confirmed or theoretical hazards of these procedures are sparse and sometimes contradictory. The purpose of this review will summarize data and opinions about one of the most disputed risks, the potential hazard of contamination and disease transmission through cryopreservation. Special attention is concentrated on the weak points of the technology including open vitrification systems, sterilization of liquid nitrogen and safety of commonly used storage tanks including straws and cryovials. Suggestions are also made for practical measures to avoid these dangers while preserving the benefits and perspectives of new cryopreservation technologies.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||cryopreservation; vitrification; freezing; contamination; liquid nitrogen|
|FoR Codes:||11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111404 Reproduction @ 100%|
|SEO Codes:||92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920114 Reproductive System and Disorders @ 100%|
|Deposited On:||30 Apr 2010 11:35|
|Last Modified:||08 Dec 2012 04:46|
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