The Schistosoma japonicum genome reveals features of host–parasite interplay
Zhou, Yan, Zheng, Huajun, Chen, Yangyi, Zhang, Lei, Wang, Kai, Guo, Jing, Huang, Zhen, Guo, Jing, Huang, Zhen, Zhang, Bo, Huang, Wei, Jin, Ke, Dou, Tonghai, Hasegawa, Masami, Wang, Li, Zhang, Yuan, Zhou, Jie, Tao, Lin, Cao, Zhiwei, Li, Yixue, Vinar, Tomas, Brejova, Brona, Brown, Dan, Li, Ming, Miller, David, Blair, David, Zhong, Yang, Chen, Zhu, Liu, Feng, Hu, Wei, Wang, Zhi-Qin, Zhang, Qin-Hua, Song, Huai-Dong, Chen, Saijuan, Xu, Xuenian, Xu, Bin, Ju, Chuan, Huang, Yucheng, Brindley, Paul, McManus, Donald, Feng, Zheng, Han, Ze-Guang, Lu, Gang, Ren, Shuangxi, Wang, Yuezhu, Wenyi, Gu, Kang, Hui, Chen, Jie, Cheng, Xiaoyun, Chen, Shuting, Wang, Lijun, Yan, Jie, Wang, Biyun, Lv, Zinyan, Jin, Lei, Wang, Bofei, Pu, Shiyin, Zhang, Xianglin, Zhang, Wei, Hu, Qiuping, Zhu, Genfeng, Wang, Jun, Yu, Jun, Wang, Jian, Yang, Huamming, Ning, Zemin, Beriman, Matthew, Wei, Chia-Lin, Ruan, Yijuan, Zhao, Guoping, and Wang, Shengyue (2009) The Schistosoma japonicum genome reveals features of host–parasite interplay. Nature, 460 . pp. 345-352.
|PDF (Published Version) - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader|
View at Publisher Website: http://dx.doi.org/10.1038/nature08140
Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation. Having a complex nervous system and a well-developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissues of its intermediate and mammalian hosts. Numerous proteases, including cercarial elastase, are implicated in mammalian skin penetration and haemoglobin degradation. The genomic information will serve as a valuable platform to facilitate development of new interventions for schistosomiasis control.
|Item Type:||Article (Refereed Research - C1)|
|Keywords:||tropical biology; Schistosoma; genome project; schistosomiasis; China; evolutionary biology|
|FoR Codes:||06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 60%|
06 BIOLOGICAL SCIENCES > 0603 Evolutionary Biology > 060307 Host-Parasite Interactions @ 40%
|SEO Codes:||97 EXPANDING KNOWLEDGE > 970106 Expanding Knowledge in the Biological Sciences @ 50%|
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
|Deposited On:||15 Apr 2010 11:13|
|Last Modified:||18 Oct 2013 01:00|
Last 12 Months: 0
|Citation Counts with External Providers:|
Repository Staff Only: item control page